Description

m-Peg7-Nhs Ester is a heterobifunctional polyethylene glycol (PEG) derivative featuring an amine-reactive N-hydroxysuccinimide (NHS) ester group at one terminus. This compound is engineered to facilitate the efficient and stable conjugation of biomolecules, such as peptides, proteins, and antibodies, to other functional groups or surfaces. It is an essential reagent for researchers and manufacturers in the fields of bioconjugation, pharmaceutical development, and advanced material science, enabling the creation of PEGylated therapeutics, diagnostic probes, and functionalized nanomaterials.

Application

• Bioconjugation and PEGylation: Primary reagent for attaching PEG chains to amine-containing drugs, proteins, or peptides to improve solubility, stability, and pharmacokinetics.
• Diagnostic Reagent Synthesis: Used to label antibodies, enzymes, or other detection molecules with fluorescent dyes or other tags via amine coupling for immunoassays and biosensors.
• Drug Delivery System Development: Facilitates the functionalization of liposomes, nanoparticles, and polymeric micelles with targeting ligands or stealth PEG layers.
• Surface Modification: Enables the covalent attachment of bioactive molecules to amine-functionalized surfaces for creating biochips, biosensors, and cell culture substrates.
• Crosslinking Agent: Serves as a homobifunctional crosslinker for amine-amine conjugation in the preparation of hydrogels or protein complexes.
• ADC (Antibody-Drug Conjugate) Linker Chemistry: A component in the construction of cleavable or non-cleavable linkers for connecting cytotoxic payloads to monoclonal antibodies.

Basic Information

Product Name	m-Peg7-Nhs Ester
CAS No.	874208-92-1
Molecular Formula	C24H43NO12
Molecular Weight	537.60 g/mol
Synonyms	m-PEG7-NHS ester; α-Methoxy-ω-succinimidyloxy poly(ethylene glycol) (MW ~350); Methoxy-PEG7-NHS ester; mPEG7-SCM; mPEG7-NHS; mPEG7-Succinimidyl Carboxymethyl Ester; 2,5-Dioxopyrrolidin-1-yl 3,6,9,12,15,18,21-heptaoxatricosan-23-oate; NHS-PEG7-OMe
EINECS	Contact for details

Quality Control

Our m-Peg7-Nhs Ester is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white waxy solid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.