Description

1-Bromo-4-(4-(trifluoromethoxy)phenoxy)benzene is a high-purity, advanced organic intermediate featuring a brominated biphenyl ether core with a trifluoromethoxy substituent. This compound is valued for its unique combination of aromatic bromine reactivity and the electron-withdrawing, lipophilic trifluoromethoxy group, making it a critical building block in sophisticated synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic applications, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Polymer & Material Science: Employed as a monomer or cross-linking agent to introduce aromatic ether and fluorine content into high-performance polymers, coatings, and adhesives.
• Cross-Coupling Reactions: The aryl bromide moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl structures.
• Chemical Research & Development: A versatile building block in academic and industrial R&D for exploring new chemical entities and reaction pathways in organic synthesis.

Basic Information

Item	Detail
Product Name	1-Bromo-4-(4-(Trifluoromethoxy)Phenoxy)Benzene
CAS No.	873203-36-2
Molecular Formula	C13H8BrF3O2
Molecular Weight	333.10 g/mol
Synonyms	4-Bromo-4'-(trifluoromethoxy)diphenyl ether; 1-Bromo-4-[4-(trifluoromethoxy)phenoxy]benzene; p-Bromophenyl 4-(trifluoromethoxy)phenyl ether; [1,1'-Biphenyl]-4-ol, 4'-bromo-4-(trifluoromethoxy)-; 4'-(Trifluoromethoxy)-4-bromodiphenyl ether
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(4-(trifluoromethoxy)phenoxy)benzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP or research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.