Description

HOOC-PEG(8)-SS-PEG(8)-COOH is a heterobifunctional polyethylene glycol (PEG) derivative featuring a central disulfide (SS) bond and terminal carboxylic acid (COOH) groups. This unique structure makes it a critical reagent for creating cleavable, stimuli-responsive linkages in bioconjugation and advanced material synthesis. It is primarily used by researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, reversible crosslinking strategies. The compound enables the development of smart drug delivery systems and functional biomaterials where controlled release under specific biological conditions is essential.

Application

• Cleavable Linker for Drug Conjugates: Used to attach cytotoxic drugs to antibodies or targeting ligands, allowing for controlled release in the reducing environment of target cells (e.g., in ADC development).
• Stimuli-Responsive Biomaterial Fabrication: Serves as a crosslinker in hydrogels and polymer networks designed to degrade or change properties in response to glutathione or other reducing agents.
• Reversible Protein PEGylation: Enables the temporary modification of therapeutic proteins to enhance pharmacokinetics, with the potential for cleavage to restore native protein activity at the site of action.
• Surface Functionalization: Used to create labile coatings on nanoparticles or diagnostic agents, facilitating targeted accumulation and subsequent payload release.
• Bioconjugation Research: A key tool in academic and industrial R&D for exploring new redox-sensitive delivery platforms and bioresponsive materials.

Basic Information

Product Name	HOOC-PEG(8)-SS-PEG(8)-COOH
CAS No.	873013-93-5
Molecular Formula	C37H72O20S2
Molecular Weight	925.1 g/mol (Theoretical)
Synonyms	α,ω-Bis(carboxy)-disulfide-PEG8; Disulfide-bis-PEG8-acid; Carboxy-PEG8-SS-PEG8-carboxylic acid; 3,6,9,12,15,18,21,24-Octaoxahexacosane-1,26-dioic acid, 26-[(13-carboxy-3,6,9,12-tetraoxatridecyl)dithio]-; HO-PEG(8)-SS-PEG(8)-OH (precursor); PEG8-disulfide-PEG8-diacid; Bis(carboxypolyethylene glycol) disulfide; 8-Arm PEG disulfide diacid
EINECS	Contact for details

Quality Control

Our HOOC-PEG(8)-SS-PEG(8)-COOH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) are provided, detailing key parameters such as assay purity, functional group integrity, and disulfide bond content. We support cGMP-grade production for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For optimal performance, use immediately after opening or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95%
Functional Group (COOH) Content	≥ 90% of theoretical
Disulfide Bond Integrity	Conforms (by NMR/LC-MS)
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.