Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl Phg(4-F)-Oh is a specialized, high-purity amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is critical for introducing the 4-fluorophenylglycine (Phg(4-F)) residue, a non-natural amino acid known for enhancing the metabolic stability and binding affinity of therapeutic peptides. It is an essential building block for researchers and manufacturers in pharmaceutical development, peptide chemistry, and agrochemical research who require reliable, high-quality intermediates for creating novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Pharmaceutical Intermediates: Key precursor in the development of peptide-based drugs targeting GPCRs, enzymes, and other biological targets.
• Structure-Activity Relationship (SAR) Studies: Used to incorporate fluorinated phenylglycine analogs to study the impact of fluorination on peptide potency and stability.
• Agrochemical Research: Building block for the synthesis of novel peptide-inspired bioactive compounds for crop protection.
• Bioconjugation: Useful for creating labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.
• Academic & Institutional Research: Fundamental reagent for chemical biology and medicinal chemistry projects in university and R&D laboratory settings.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl Phg(4-F)-Oh
CAS No.	872359-16-5
Molecular Formula	C24H20FNO4
Molecular Weight	405.42 g/mol
Synonyms	Fmoc-4-fluoro-DL-phenylglycine; Fmoc-4-F-Phg-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-fluorophenylglycine; Fmoc-DL-4-fluorophenylglycine; N-Fmoc-4-fluorophenylglycine; Fmoc-4-fluoro-α-phenylglycine; (9-Fluorenylmethyloxycarbonyl)-4-fluorophenylglycine; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-(4-fluorophenyl)acetic acid
EINECS	Contact for details

Quality Control

Our production of (9H-Fluoren-9-Yl)Methoxy]Carbonyl Phg(4-F)-Oh adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive research and manufacturing applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Contact for details (DL or enantiopure grades available)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.