Description

2,5-Difluoro-4-Methylphenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop novel active ingredients and functional organic compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates which often exhibit enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in constructing novel herbicides, fungicides, and insecticides, where the difluoro-methylphenyl moiety can contribute to improved efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis and other advanced catalytic processes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors).
• Chemical Biology & Diagnostics: Utilized in the preparation of molecular probes and sensor materials that leverage boronic acid's affinity for diols.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs (Contract Research Organizations) serving the global life sciences industry.

Basic Information

Product Name	2,5-Difluoro-4-Methylphenylboronic Acid
CAS No.	872219-20-0
Molecular Formula	C7H7BF2O2
Molecular Weight	171.94 g/mol
Synonyms	(2,5-Difluoro-4-methylphenyl)boronic acid; 4-Methyl-2,5-difluorophenylboronic acid; 2,5-Difluoro-p-tolylboronic acid; Boronic acid, B-(2,5-difluoro-4-methylphenyl)-; 872219-20-0; 2,5-Difluoro-4-methylbenzeneboronic acid
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluoro-4-Methylphenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality commitment supports applications in cGMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Purity (NMR)	≥95.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.