Description

2-(3-Fluoro-2-Nitrophenyl)Acetic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the fluorine and nitro substituents enable precise modulation of biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluoronitrophenyl motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the fluoronitrophenyl group can enhance bioavailability and target specificity.
• Ligand and Catalyst Development: Employed as a building block for creating novel chelating ligands or organocatalysts used in asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Research: Acts as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, or organic electronic materials with tailored properties.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorescent tags, photoaffinity labels, or other molecular probes for studying biological systems.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-(3-Fluoro-2-Nitrophenyl)Acetic Acid
CAS No.	872141-25-8
Molecular Formula	C8H6FNO4
Molecular Weight	199.14 g/mol
Synonyms	(3-Fluoro-2-nitrophenyl)acetic acid; 2-Nitro-3-fluorophenylacetic acid; 2-(3-Fluoro-2-nitrophenyl)ethanoic acid; α-Carboxy-3-fluoro-2-nitrotoluene; 3-Fluoro-2-nitrophenylacetic acid; 872141-25-8; (3-Fluoro-2-nitrobenzyl)formic acid (deprecated)
EINECS	Contact for details

Quality Control

Our 2-(3-Fluoro-2-Nitrophenyl)Acetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.