Description

Benzene, 2-Ethoxy-1-Fluoro-3-Iodo- is a highly functionalized halogenated benzene derivative, serving as a versatile and valuable building block in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty materials. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise, high-purity intermediates for coupling reactions and molecular diversification.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those requiring halogenated aromatic cores for bioactivity or further functionalization.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the iodine and fluorine atoms enable unique modes of action.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating halogenated aromatic units in electronic and photonic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings.
• Fluorine Chemistry Research: A valuable compound for studying the effects of fluorine substitution on aromatic systems in medicinal and materials chemistry.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Benzene, 2-Ethoxy-1-Fluoro-3-Iodo-
CAS No.	871726-97-5
Molecular Formula	C8H8FIO
Molecular Weight	266.05 g/mol
Synonyms	1-Ethoxy-2-fluoro-3-iodobenzene; 2-Ethoxy-1-fluoro-3-iodobenzene; 3-Iodo-2-ethoxy-1-fluorobenzene; 1-Fluoro-2-ethoxy-3-iodobenzene; 2-Fluoro-6-iodophenetole; o-Ethoxy-m-iodofluorobenzene; Benzene, 1-ethoxy-2-fluoro-3-iodo-
EINECS	Contact for details

Quality Control

Our Benzene, 2-Ethoxy-1-Fluoro-3-Iodo- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture ingress and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.