Description

1-Bromo-2-Ethoxy-4-Fluorobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in its unique substitution pattern, which makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and materials science industries for applications such as drug discovery and the development of specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atom and bromo-ethoxy motif can improve biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the development of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, enabling the introduction of complex aryl groups.
• Functional Polymer Monomer: Employed in the creation of specialty polymers with specific optical, electronic, or surface properties.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry teams exploring new synthetic pathways and novel compound libraries.

Basic Information

Product Name	1-Bromo-2-Ethoxy-4-Fluorobenzene
CAS No.	871717-61-2
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	2-Bromo-1-Ethoxy-4-Fluorobenzene; 4-Fluoro-2-Bromophenetole; 1-Ethoxy-2-Bromo-4-Fluorobenzene; 2-Bromo-4-Fluorophenetole; Benzene, 1-bromo-2-ethoxy-4-fluoro-; 4-Fluoro-2-bromo-1-ethoxybenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Ethoxy-4-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.