Description

3-Bromo-2-Methoxybenzotrifluoride is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring bromine and methoxy substituents on a trifluoromethylated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides that require fluorinated aromatic cores for enhanced activity and environmental stability.
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom provides an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira) to create more complex biaryl and conjugated systems.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for biological screening.
• Ligand and Catalyst Design: Useful for synthesizing novel ligands and organocatalysts where the electron-withdrawing trifluoromethyl group can modulate reactivity and selectivity.

Basic Information

Item	Detail
Product Name	3-Bromo-2-Methoxybenzotrifluoride
CAS No.	871352-91-9
Molecular Formula	C9H6BrF3O
Molecular Weight	255.04 g/mol
Synonyms	2-Bromo-6-methoxy-α,α,α-trifluorotoluene; 1-Bromo-2-methoxy-3-(trifluoromethyl)benzene; 3-Bromo-2-methoxy-α,α,α-trifluorotoluene; 2-Methoxy-3-bromobenzotrifluoride; 3-Bromo-2-(trifluoromethyl)anisole; 2-Bromo-6-methoxybenzotrifluoride
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-2-Methoxybenzotrifluoride is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process chemistry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 25°C. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.