Description

4-Chloro-3-(Pyrrolidine-1-Carbonyl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its molecular architecture, featuring both a boronic acid group and a pyrrolidine amide moiety, makes it a versatile intermediate for constructing complex molecules via cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require high-purity, functionalized intermediates for drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used to create advanced herbicides and fungicides with specific targeting properties by introducing the chlorophenyl boronic acid scaffold into larger molecules.
• Material Science Research: Employed in the development of organic electronic materials, such as polymers for OLEDs, where its structure aids in tuning electronic properties.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized to create boronic acid-based probes for sensing and protein labeling applications, leveraging its specific binding affinity.
• Custom Synthesis & Contract Manufacturing: A valuable substrate for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Chloro-3-(Pyrrolidine-1-Carbonyl)Phenylboronic Acid
CAS No.	871332-75-1
Molecular Formula	C11H13BClNO3
Molecular Weight	253.49 g/mol
Synonyms	[4-Chloro-3-(pyrrolidine-1-carbonyl)phenyl]boronic acid; (4-Chloro-3-(pyrrolidine-1-carbonyl)phenyl)boronic acid; Boronic acid, B-[4-chloro-3-(1-pyrrolidinylcarbonyl)phenyl]-; 4-Chloro-3-(1-pyrrolidinylcarbonyl)benzeneboronic acid; 3-Carbamoyl-4-chlorophenylboronic acid pyrrolidine derivative; CAS 871332-75-1
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-(Pyrrolidine-1-Carbonyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.