Description

4-Butoxy-2,3,5,6-Tetrafluorobenzeneboronic Acid is a specialized organoboron compound featuring a tetrafluorinated aromatic ring, making it a valuable building block in modern synthetic chemistry. Its primary value lies in its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides where the introduction of the fluorinated phenylboronic acid moiety enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or building block for synthesizing advanced polymers, liquid crystals, and organic electronic materials (OLEDs, OFETs) due to its unique electronic properties imparted by fluorine atoms.
• Suzuki-Miyaura Cross-Coupling: The principal application is as a coupling partner with various organic halides or triflates to form carbon-carbon bonds under palladium catalysis, a cornerstone reaction in medicinal and process chemistry.
• Chemical Biology & Proteomics: Can be utilized in bioconjugation strategies and as a handle for developing chemical probes and activity-based protein profiling (ABPP) agents.
• Catalyst Ligand Development: The boronic acid group and fluorine substitution pattern make it a candidate for developing novel ligands in asymmetric catalysis.

Basic Information

Product Name	4-Butoxy-2,3,5,6-Tetrafluorobenzeneboronic Acid
CAS No.	871126-19-1
Molecular Formula	C₁₀H₁₁BF₄O₃
Molecular Weight	266.00 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-butoxybenzeneboronic Acid; (4-Butoxy-2,3,5,6-tetrafluorophenyl)boronic Acid; 4-n-Butoxy-2,3,5,6-tetrafluorophenylboronic Acid; B-(4-Butoxy-2,3,5,6-tetrafluorophenyl)boronic Acid; 4-Butoxy-2,3,5,6-tetrafluorophenyl-Boronic Acid; 871126-19-1; Tetrafluorobutoxyphenylboronic Acid
EINECS	Contact for details

Quality Control

Our 4-Butoxy-2,3,5,6-Tetrafluorobenzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.