Description

3-Chloro-4-(Trifluoromethoxy)Phenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl structures.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific halogenated and fluorinated motifs for enhanced activity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated ligands for transition metal catalysis and organoboron reagents.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and sensors for biochemical research and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CROs/CMOs serving the global life sciences industry.

Basic Information

Product Name	3-Chloro-4-(Trifluoromethoxy)Phenylboronic Acid
CAS No.	870822-79-0
Molecular Formula	C7H5BClF3O3
Molecular Weight	239.38 g/mol
Synonyms	[3-Chloro-4-(trifluoromethoxy)phenyl]boronic acid; (3-Chloro-4-(trifluoromethoxy)phenyl)boronic acid; Boronic acid, B-[3-chloro-4-(trifluoromethoxy)phenyl]-; 3-Chloro-4-trifluoromethoxybenzeneboronic acid; 3-Chloro-4-(trifluoromethoxy)benzeneboronic acid; 870822-79-0; AKOS005258315
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-(Trifluoromethoxy)Phenylboronic Acid is manufactured and tested under a strict quality management system. We ensure compliance with rigorous internal specifications, which are designed to meet the demanding requirements of research and commercial-scale synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	Conforms
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.