Description

Boronic Acid, [8-(Trifluoromethoxy)-2-Naphthalenyl]- (9Ci) is a specialized organoboron compound featuring a naphthalene core functionalized with a trifluoromethoxy group. This structure makes it a valuable and versatile building block in modern synthetic chemistry, particularly for cross-coupling reactions. It is primarily utilized by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients. Its unique electronic properties, imparted by the trifluoromethoxy substituent, are crucial for modulating the biological activity and physicochemical properties of target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing complex biaryl structures found in drug candidates.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances lipophilicity and metabolic stability.
• Material Science: Serves as a monomer or functionalization agent in the development of advanced organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry and the development of enzyme inhibitors or receptor ligands.
• Catalyst Ligand Synthesis: Utilized to create sophisticated ligand systems for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical suppliers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	Boronic Acid, [8-(Trifluoromethoxy)-2-Naphthalenyl]- (9Ci)
CAS No.	870822-76-7
Molecular Formula	C₁₁H₈BF₃O₃
Molecular Weight	256.0 g/mol
Synonyms	[8-(Trifluoromethoxy)-2-naphthyl]boronic acid; 2-(Trifluoromethoxynaphthalen-8-yl)boronic acid; 8-Trifluoromethoxy-2-naphthaleneboronic acid; (8-Trifluoromethoxynaphthalen-2-yl)boronic acid; Boronic acid, B-[8-(trifluoromethoxy)-2-naphthalenyl]-; 2-Borono-8-(trifluoromethoxy)naphthalene
EINECS	Contact for details

Quality Control

Every batch of Boronic Acid, [8-(Trifluoromethoxy)-2-Naphthalenyl]- (9Ci) is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.