Description

3-Bromo-2-(2'-Fluorobenzyloxy)Phenylbor& is a specialized organoboron compound that serves as a crucial synthetic intermediate in modern organic chemistry. Its value lies in its unique molecular architecture, which combines a bromo-substituted phenyl ring with a fluorobenzyloxy group and a boronic acid/ester functionality, making it a versatile building block for cross-coupling reactions. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules and developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine and bromine substituents can enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the synthesis of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology Probes: Employed in the creation of bioconjugates and molecular probes for studying biological pathways and protein interactions.
• Catalyst Ligand Development: The boronic acid moiety can be utilized to develop novel ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A critical component for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing high-value, low-volume specialty chemicals for clients.

Basic Information

Product Name	3-Bromo-2-(2'-Fluorobenzyloxy)Phenylbor&
CAS No.	870778-86-2
Molecular Formula	C₁₃H₁₁BBrFO₂
Molecular Weight	309.94 g/mol
Synonyms	[2-Bromo-6-(2-fluorobenzyloxy)phenyl]boronic acid; 3-Bromo-2-[(2-fluorophenyl)methoxy]benzeneboronic acid; 2-(2-Fluorobenzyloxy)-3-bromophenylboronic acid; Boronic acid, B-[2-bromo-6-[(2-fluorophenyl)methoxy]phenyl]-; 870778-86-2; 3-Bromo-2-(2-fluorobenzyloxy)phenylboronic acid; (3-Bromo-2-((2-fluorobenzyl)oxy)phenyl)boronic acid
EINECS	Contact for details

Quality Control

Our production of 3-Bromo-2-(2'-Fluorobenzyloxy)Phenylbor& adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR (¹H, ¹³C, ¹¹B), HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We operate under a quality management system and can support development projects requiring compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.