Description

4,5-Difluoro-2-Methoxyphenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly in the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing difluoromethoxy-substituted aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific fluorinated aromatic motifs.
• Ligand and Catalyst Development: Serves as a building block for creating novel ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic units enhance stability and performance.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for biochemical and pharmacological studies.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs serving the life sciences industry.

Basic Information

Product Name	4,5-Difluoro-2-Methoxyphenylboronic Acid
CAS No.	870777-32-5
Molecular Formula	C7H7BF2O3
Molecular Weight	187.94 g/mol
Synonyms	(4,5-Difluoro-2-methoxyphenyl)boronic acid; 2-Methoxy-4,5-difluorophenylboronic acid; 4,5-Difluoro-2-methoxybenzeneboronic acid; Boronic acid, B-(4,5-difluoro-2-methoxyphenyl)-; 870777-32-5; 4,5-Difluoro-o-anisylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 4,5-Difluoro-2-Methoxyphenylboronic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing. We ensure compliance with stringent in-house specifications, which are aligned with industry standards for fine chemical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.