Description

3,3-Difluoro-2-(2-Indolinylmethyl)Acrylic Acid is a high-value, multi-functional fluorinated building block and intermediate. Its unique molecular architecture, featuring a difluoroacrylic acid moiety fused with an indoline ring system, makes it a critical precursor for synthesizing complex molecules with tailored properties. This compound is primarily sought after by research institutions and pharmaceutical developers engaged in medicinal chemistry and advanced material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly protease inhibitors and kinase-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce fluorine atoms, enhancing metabolic stability and bioavailability.
• Fluorinated Compound Synthesis: Serves as a versatile precursor for creating a wide range of fluorinated heterocycles and complex organic molecules.
• Agrochemical Development: Employed in the research and synthesis of new-generation fluorinated pesticides and herbicides.
• Material Science Precursor: Potential use in developing specialty polymers and advanced organic electronic materials due to its conjugated system.
• Chemical Biology Probes: Useful for designing fluorinated probes and ligands for studying biological targets and mechanisms.

Basic Information

Product Name	3,3-Difluoro-2-(2-Indolinylmethyl)Acrylic Acid
CAS No.	870703-88-1
Molecular Formula	C₁₄H₁₃F₂NO₂
Molecular Weight	265.26 g/mol
Synonyms	3,3-Difluoro-2-(indolin-2-ylmethyl)acrylic acid; 2-(2,3-Dihydro-1H-indol-2-ylmethyl)-3,3-difluoroacrylic acid; 3,3-Difluoro-2-(2-indolinylmethyl)-2-propenoic acid; 870703-88-1; DFIMA; (Z)-3,3-Difluoro-2-((2,3-dihydro-1H-indol-2-yl)methyl)acrylic acid
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-2-(2-Indolinylmethyl)Acrylic Acid is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.