Description

1-(5-Chloro-2-Hydroxyphenyl)-2,2,2-Trifluoroethan-1-One is a high-value trifluoromethyl ketone derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both a phenolic hydroxyl and a reactive trifluoroacetyl group, makes it indispensable for constructing complex molecules with tailored properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly those requiring the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the chloro and trifluoromethyl motifs are common pharmacophores.
• Material Science Research: Serves as a precursor for specialty polymers and advanced organic materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized in the development of enzyme inhibitors and molecular probes for biochemical research due to its reactive ketone functionality.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	1-(5-Chloro-2-Hydroxyphenyl)-2,2,2-Trifluoroethan-1-One
CAS No.	870614-04-3
Molecular Formula	C8H4ClF3O2
Molecular Weight	224.56 g/mol
Synonyms	5'-Chloro-2'-hydroxy-2,2,2-trifluoroacetophenone; 2,2,2-Trifluoro-1-(5-chloro-2-hydroxyphenyl)ethanone; 1-(5-Chloro-2-hydroxyphenyl)-2,2,2-trifluoroethanone; 5-Chloro-2-hydroxy-α,α,α-trifluoroacetophenone; 2-Hydroxy-5-chloro-α,α,α-trifluoroacetophenone; TFAP-CI-OH (common abbreviation); (5-Chloro-2-hydroxyphenyl)(trifluoromethyl)methanone
EINECS	Contact for details

Quality Control

Our production of 1-(5-Chloro-2-Hydroxyphenyl)-2,2,2-Trifluoroethan-1-One adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.