Description

Fmoc-Cit-Paba CAS NO 870487-04-0 is a specialized, high-purity protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over peptide chain assembly, particularly for introducing citrulline residues. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic laboratories engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled, sequential assembly of peptides on resin supports.
• Peptidomimetic Drug Discovery: Used in the research and development of peptide-based therapeutics targeting various diseases.
• Bioconjugation and Probe Synthesis: Facilitates the creation of labeled peptides for diagnostic, imaging, and biochemical studies.
• Antibody-Drug Conjugate (ADC) Linker Research: Serves as a component in the design of sophisticated linker systems for targeted cancer therapies.
• Enzyme Substrate and Inhibitor Design: Employed to synthesize specific substrates or inhibitors for enzymes like PAD (Peptidyl Arginine Deiminase).
• Custom Peptide Service Production: An essential raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Fmoc-Cit-Paba
CAS No.	870487-04-0
Molecular Formula	C26H23N3O6
Molecular Weight	473.48 g/mol
Synonyms	Fmoc-Cit-PABA; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N5-[(4-aminobenzoyl)]-L-ornithine; Fmoc-Citrulline-PABA; Fmoc-L-Cit-PABA-OH; N-α-Fmoc-N-δ-(4-aminobenzoyl)-L-citrulline; N-α-Fmoc-N-ω-(4-aminobenzoyl)-L-citrulline; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((4-aminobenzoyl)amino)pentanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Cit-Paba is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric purity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research and cGMP-grade production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.