Description

2-Chloro-5-Fluorobenzeneboronic Acid Pinacol Ester, 96% is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides requiring specific halogenated biphenyl structures.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and semiconductors.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in proteomics and diagnostic assay development.
• Custom Fine Chemical Production: Integral for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	2-Chloro-5-Fluorobenzeneboronic Acid Pinacol Ester, 96%
CAS No.	870486-41-2
Molecular Formula	C12H15BClFO2
Molecular Weight	255.51 g/mol
Synonyms	2-Chloro-5-fluorophenylboronic acid pinacol ester; (2-Chloro-5-fluorophenyl)boronic acid pinacol ester; Pinacol (2-chloro-5-fluorophenyl)boronate; 5-Chloro-2-fluorobenzeneboronic acid pinacol ester; 2-Chloro-5-fluoro-1,3,2-benzodioxaborole, 4,4,5,5-tetramethyl-; 4,4,5,5-Tetramethyl-2-(2-chloro-5-fluorophenyl)-1,3,2-dioxaborolane; Boronic acid, B-(2-chloro-5-fluorophenyl)-, 1,1-dimethylethyl ester (9CI)
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluorobenzeneboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the original container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 96.0%
Purity (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.