Description

2'-Dicyclohexylphosphino-2,6-dimethoxy-3-sulfonato-1,1'-biphenyl hydrate sodium salt is a highly specialized, water-soluble phosphine ligand, a key component in modern catalytic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig amination, under mild aqueous or biphasic conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require robust, selective catalysts for synthesizing complex organic molecules and active pharmaceutical ingredients (APIs).

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A critical ligand for palladium-catalyzed carbon-carbon bond formation between aryl/vinyl boronic acids and halides, widely used in pharmaceutical intermediate synthesis.
• Buchwald-Hartwig Amination: Facilitates palladium-catalyzed carbon-nitrogen bond coupling for the synthesis of aryl amines, a key step in many drug molecules.
• Aqueous-Phase Catalysis: Its sulfonated, water-soluble nature allows for catalytic reactions in water or water/organic solvent mixtures, enabling greener and more sustainable chemical processes.
• Pharmaceutical Intermediate Manufacturing: Used in the scalable production of complex, high-value intermediates and active pharmaceutical ingredients (APIs) under process-friendly conditions.
• Agrochemical Synthesis: Applied in the catalytic synthesis of advanced herbicides, fungicides, and insecticides requiring selective coupling steps.
• Fine Chemical and Specialty Material Production: Enables the synthesis of conjugated polymers, liquid crystals, and other advanced materials through efficient cross-coupling methodologies.
• Academic and Industrial R&D: A valuable tool for discovery chemistry and process development in both laboratory and pilot-scale settings.

Basic Information

Product Name	2'-Dicyclohexylphosphino-2,6-dimethoxy-3-sulfonato-1,1'-biphenyl hydrate sodium salt
CAS No.	870245-75-3
Molecular Formula	C26H34NaO6PS · xH2O
Molecular Weight	528.57 g/mol (anhydrous basis)
Synonyms	SPhos Sulfonate Sodium Salt; 2-Dicyclohexylphosphino-2',6'-dimethoxy-3-sulfonato-1,1'-biphenyl Sodium Salt; Sodium 2'-Dicyclohexylphosphino-2,6-dimethoxy[1,1'-biphenyl]-3-sulfonate Hydrate; Sulfonated SPhos Sodium Salt; Water-Soluble SPhos Ligand; SPhos-SO3Na; 2-Dicyclohexylphosphino-2',6'-dimethoxy-3-sodium sulfonate-1,1'-biphenyl; CAS 870245-75-3.
EINECS	Contact for details

Quality Control

Our production of 2'-Dicyclohexylphosphino-2,6-dimethoxy-3-sulfonato-1,1'-biphenyl hydrate sodium salt adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot is characterized by advanced analytical techniques including NMR (1H, 13C, 31P), HPLC, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, residual solvent levels, and moisture content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥95.0%
Purity (NMR)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.