Description

1-Bromo-4-Fluoro-2-(2,2,2-Trifluoroethoxy)Benzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a trifluoroethoxy substituent, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Serves as a versatile precursor for novel herbicides, fungicides, and insecticides, where the fluorine and trifluoroethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Used in the research and production of advanced electronic materials, where its aromatic core and halogen substituents contribute to desired dielectric and luminescent properties.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl and conjugated systems.
• Fluorine Chemistry Research: An important substrate for studying nucleophilic aromatic substitution and other reactions influenced by the strong electron-withdrawing trifluoroethoxy group.
• Polymer Modification: Can be incorporated as a monomer or modifier to impart flame retardancy, chemical resistance, and specific solubility characteristics to high-performance polymers.

Basic Information

Product Name	1-Bromo-4-Fluoro-2-(2,2,2-Trifluoroethoxy)Benzene
CAS No.	870063-18-6
Molecular Formula	C8H5BrF4O
Molecular Weight	273.03 g/mol
Synonyms	2-Bromo-5-Fluoro(2,2,2-trifluoroethoxy)benzene; 4-Fluoro-2-(2,2,2-trifluoroethoxy)bromobenzene; 1-Bromo-4-fluoro-2-(trifluoroethoxy)benzene; Benzene, 1-bromo-4-fluoro-2-(2,2,2-trifluoroethoxy)-; 2-(2,2,2-Trifluoroethoxy)-4-fluorobromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Fluoro-2-(2,2,2-Trifluoroethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.