Description

T-Boc-n-Amido-Peg2-Propargyl is a specialized bifunctional polyethylene glycol (PEG) linker featuring a tert-butyloxycarbonyl (T-Boc) protected amine and a terminal propargyl group. This compound is engineered for high-value applications in bioconjugation and pharmaceutical development, serving as a critical building block for creating stable, cleavable linkages. It is primarily utilized by researchers and manufacturers in the fields of proteomics, antibody-drug conjugate (ADC) development, and advanced material science.

Application

• Bioconjugation Reagent: Used for site-specific conjugation of biomolecules (e.g., peptides, proteins, antibodies) via click chemistry (CuAAC) utilizing the propargyl group.
• Antibody-Drug Conjugate (ADC) Linker: Serves as a key component in the synthesis of ADCs, providing a hydrophilic PEG spacer to improve solubility and pharmacokinetics, with a cleavable T-Boc-protected amine for payload attachment.
• Proteomics Research: Employed in the synthesis of activity-based probes (ABPs) and affinity tags for studying enzyme function and protein interactions.
• Polymer and Material Science: Acts as a functional monomer or cross-linker for creating smart hydrogels, surface coatings, and drug delivery systems with tailored properties.
• Diagnostic Reagent Synthesis: Utilized in the development of diagnostic assays and imaging agents where controlled conjugation is required.

Basic Information

Product Name	T-Boc-n-Amido-Peg2-Propargyl
CAS No.	869310-84-9
Molecular Formula	C17H31NO6
Molecular Weight	345.44 g/mol
Synonyms	1-Boc-3,6,9,12-tetraoxapentadec-14-yn-15-amine; 2,5,8,11-Tetraoxatetradec-13-yn-14-amine, 1-(1,1-dimethylethoxy)carbonyl]-; T-Boc-N-amido-PEG2-propargyl; Boc-NH-PEG2-propargyl; tert-Butyl (17-amino-3,6,9,12-tetraoxa-16-heptadecyn-1-yl)carbamate; Propargyl-PEG2-NH-Boc; N-(tert-Butoxycarbonyl)-3,6,9,12-tetraoxapentadec-14-yn-1-amine
EINECS	Contact for details

Quality Control

Our T-Boc-n-Amido-Peg2-Propargyl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and pharmaceutical applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.