Description

(S)-2-(((Benzyloxy)Carbonyl)Amino)Pent-4-Ynoic Acid is a chiral, non-proteinogenic amino acid derivative featuring a terminal alkyne functional group, making it a versatile building block for advanced organic synthesis. This compound is valued for its role as a key intermediate in the preparation of peptidomimetics, enzyme inhibitors, and other biologically active molecules. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and fine chemical manufacturers engaged in drug discovery and development.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates, particularly in protease inhibitor and peptide-based therapeutic research.
• Peptidomimetic Synthesis: Used to construct peptide analogs where the alkyne handle enables site-specific modifications via click chemistry (e.g., CuAAC).
• Bioconjugation & Probe Development: The terminal alkyne allows for efficient labeling and conjugation with azide-containing biomolecules, fluorophores, or solid supports for chemical biology studies.
• Chemical Library Construction: Serves as a building block in combinatorial chemistry for generating diverse compound libraries for high-throughput screening.
• Academic & Industrial Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized fine chemicals for client projects.

Basic Information

Product Name	(S)-2-(((Benzyloxy)Carbonyl)Amino)Pent-4-Ynoic Acid
CAS No.	869116-13-2
Molecular Formula	C14H15NO4
Molecular Weight	261.27 g/mol
Synonyms	(S)-2-((((Benzyloxy)carbonyl)amino)pent-4-ynoic acid; (S)-Cbz-Amino-pent-4-ynoic Acid; (S)-N-Carbobenzoxy-2-amino-4-pentynoic Acid; (S)-N-Cbz-2-amino-4-pentynoic Acid; (2S)-2-({[(Benzyloxy)carbonyl]amino}pent-4-ynoic acid; Z-(S)-Amino-pent-4-ynoic Acid; (S)-2-(Cbz-amino)-4-pentynoic Acid; (S)-Nα-Cbz-2,4-didehydrohomophenylalanine
EINECS	Contact for details

Quality Control

Our (S)-2-(((Benzyloxy)Carbonyl)Amino)Pent-4-Ynoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.