Description

Fmoc-β-Iodo-L-Ala-Obzl CAS NO 869107-32-4 is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound is a critical building block for introducing iodine-labeled or modified alanine residues into peptide chains, enabling the study of protein structure, function, and the development of novel therapeutics. It is primarily utilized by research scientists and process development chemists in the pharmaceutical, biotechnology, and academic sectors. The Fmoc protecting group ensures compatibility with standard solid-phase peptide synthesis (SPPS) protocols.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a key reagent for the automated synthesis of custom peptides containing iodine-modified alanine.
• Medicinal Chemistry & Drug Discovery: Used to incorporate iodine atoms into peptide-based drug candidates for structure-activity relationship (SAR) studies, radiolabeling precursors, or to modulate pharmacokinetic properties.
• Chemical Biology Probes: Serves as a building block for creating peptide probes used in imaging, target identification, and studying biomolecular interactions.
• Bioconjugation: The iodine atom and benzyl ester can be utilized for further selective chemical modifications and cross-linking reactions.
• Academic Research: Fundamental research in organic synthesis, peptide mimetics, and the development of new synthetic methodologies.

Basic Information

Product Name	Fmoc-β-Iodo-L-Ala-Obzl
CAS No.	869107-32-4
Molecular Formula	C25H22INO4
Molecular Weight	527.35 g/mol
Synonyms	Fmoc-β-Iodo-L-alanine benzyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-iodo-L-alanine benzyl ester; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-iodopropanoic acid benzyl ester; Fmoc-L-β-Iodoalanine-OBzl; Fmoc-3-Iodo-L-alanine benzyl ester; N-Fmoc-3-iodo-L-alanine benzyl ester; Benzyl (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-iodopropanoate
EINECS	Contact for details

Quality Control

Our Fmoc-β-Iodo-L-Ala-Obzl is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.