Description

n-Boc-4-Bromo-3-Fluoroaniline is a high-purity, protected aniline derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive aromatic scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This intermediate is essential for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the halogen and fluorine substituents for bioactivity.
• Material Science: Precursor for functionalized polymers, liquid crystals, and organic electronic materials requiring specific aromatic architectures.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form complex biaryl systems.
• Peptidomimetics & PROTACs: The Boc-protected amine is instrumental in constructing peptide-like molecules and Proteolysis-Targeting Chimeras (PROTACs).
• Chemical Biology Probes: Utilized in the development of fluorescent tags, affinity labels, and other molecular probes for biological research.

Basic Information

Product Name	n-Boc-4-Bromo-3-Fluoroaniline
CAS No.	868735-43-7
Molecular Formula	C11H13BrFNO2
Molecular Weight	290.13 g/mol
Synonyms	tert-Butyl (4-bromo-3-fluorophenyl)carbamate; 1-(tert-Butoxycarbonylamino)-4-bromo-3-fluorobenzene; 4-Bromo-3-fluoroaniline, N-BOC-protected; N-Boc-4-bromo-3-fluoroaniline; N-(tert-Butoxycarbonyl)-4-bromo-3-fluoroaniline; Boc-4-Br-3-F-aniline; (4-Bromo-3-fluorophenyl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-4-Bromo-3-Fluoroaniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We are committed to meeting the stringent requirements of cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.