Description

n-(4-Cyano-2-Iodo-5-(Trifluoromethyl)-Phenyl)Methanesulfonamide is a high-value, multi-functionalized aromatic building block designed for advanced synthetic chemistry. Its core value lies in the strategic combination of electron-withdrawing groups—cyano, iodo, and trifluoromethyl—on a benzenesulfonamide scaffold, enabling precise molecular modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the development of novel active ingredients, particularly for targeted therapies and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, especially kinase inhibitors, receptor antagonists, and other small-molecule therapeutics.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl and sulfonamide groups.
• Material Science: Serves as a building block for advanced organic materials, such as liquid crystals, organic semiconductors, and polymers with specific electronic properties.
• Chemical Biology & Proteomics: Acts as a versatile scaffold for creating chemical probes and affinity labels to study enzyme function and protein interactions.
• Cross-Coupling Reactions: The aryl iodide moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	n-(4-Cyano-2-Iodo-5-(Trifluoromethyl)-Phenyl)Methanesulfonamide
CAS No.	868692-62-0
Molecular Formula	C9H6F3IN2O2S
Molecular Weight	390.12 g/mol
Synonyms	4-Cyano-2-iodo-5-(trifluoromethyl)benzenesulfonamide; N-[4-Cyano-2-iodo-5-(trifluoromethyl)phenyl]methanesulfonamide; 2-Iodo-4-cyano-5-(trifluoromethyl)benzenesulfonamide; 868692-62-0; Methanesulfonamide, N-[4-cyano-2-iodo-5-(trifluoromethyl)phenyl]-; Benzenesulfonamide, 4-cyano-2-iodo-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our production of n-(4-Cyano-2-Iodo-5-(Trifluoromethyl)-Phenyl)Methanesulfonamide adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications. Our quality system is designed to support cGMP and ISO standards for reliable, batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.