Description

Uridine, 4'-Thio-, 5'-Acetate 2',3'-Dibenzoate (9Ci) is a chemically modified nucleoside derivative, specifically a thio-substituted and benzoate-protected uridine analog. This compound is a critical building block in advanced organic synthesis and medicinal chemistry research, enabling the study of nucleic acid structure, function, and the development of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and biotech companies focused on nucleoside-based drug discovery, antisense oligonucleotide development, and biochemical probe synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor for the development of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a modified substrate to study RNA metabolism, enzyme mechanisms (e.g., kinases, polymerases), and nucleic acid-protein interactions.
• Antisense Oligonucleotide (ASO) Synthesis: Incorporated into oligonucleotide chains to modulate stability, binding affinity, and biological activity.
• Probe and Diagnostic Development: Acts as a starting material for creating labeled nucleosides used in imaging, detection, and diagnostic assays.
• Academic Research: Utilized in universities and research institutes for fundamental studies in bioorganic chemistry and chemical biology.
• Process Development: Employed in scaling up synthetic routes for potential Active Pharmaceutical Ingredients (APIs) in a GMP environment.

Basic Information

Product Name	Uridine, 4'-Thio-, 5'-Acetate 2',3'-Dibenzoate (9Ci)
CAS No.	868235-18-1
Molecular Formula	C25H22N2O8S
Molecular Weight	510.52 g/mol
Synonyms	4'-Thiouridine 5'-acetate 2',3'-dibenzoate; 2',3'-Di-O-benzoyl-5'-O-acetyl-4'-thiouridine; 4'-Thio-2',3'-di-O-benzoyl-5'-O-acetyluridine; 5'-Acetyl-2',3'-dibenzoyl-4'-thiouridine; Uridine, 4'-thio-, 5'-acetate 2',3'-dibenzoate; 4'-Thio-5'-O-acetyl-2',3'-di-O-benzoyluridine; 4'-Thiouridine derivative, 5'-Ac, 2',3'-diBz; 9CI derivative of 4'-thiouridine
EINECS	Contact for details

Quality Control

Our Uridine, 4'-Thio-, 5'-Acetate 2',3'-Dibenzoate (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. For cGMP-grade material or custom specifications, please contact our technical sales team.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.