Description

3-Methoxy-5-Trifluoromethyl Benzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique trifluoromethyl and methoxy substitution pattern offers valuable electronic and steric properties for modulating the activity of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a critical precursor for developing new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Used in the synthesis of advanced organic electronic materials, where its molecular structure contributes to desired dielectric and luminescent properties.
• Functional Polymer Monomer: Employed in the development of specialty polymers with tailored thermal stability, chemical resistance, or specific surface properties.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Chemical Research & Process Development: Utilized in academic and industrial laboratories for method development, scale-up studies, and exploring new synthetic pathways.

Basic Information

Product Name	3-Methoxy-5-Trifluoromethyl Benzonitrile
CAS No.	868167-61-7
Molecular Formula	C9H6F3NO
Molecular Weight	201.15 g/mol
Synonyms	5-(Trifluoromethyl)-3-methoxybenzonitrile; 3-Methoxy-5-(trifluoromethyl)benzonitrile; 3-Cyano-5-methoxybenzotrifluoride; 3-Methoxy-α,α,α-trifluoro-m-toluonitrile; m-Methoxy-α,α,α-trifluoro-m-cyanotoluene; Benzonitrile, 3-methoxy-5-(trifluoromethyl)-; 868167-61-7
EINECS	Contact for details

Quality Control

Our 3-Methoxy-5-Trifluoromethyl Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.