Description

3,5-Difluoro-3'-(Trifluoromethoxy)-[1,1'-Biphenyl]-4-Amine is a high-value, multi-functional aromatic amine building block characterized by its unique biphenyl core and strategically placed fluorine and trifluoromethoxy substituents. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its structure imparts desirable properties like metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for electron-transport materials, host materials, and other functional components in display and lighting technologies.
• Polymer & Resin Modifier: Incorporated into high-performance polymers to enhance thermal stability, chemical resistance, and optical properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex, fluorinated aromatic systems for various research applications.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry and material science research, enabling structure-activity relationship (SAR) studies.

Basic Information

Item	Details
Product Name	3,5-Difluoro-3'-(Trifluoromethoxy)-[1,1'-Biphenyl]-4-Amine
CAS No.	867288-01-5
Molecular Formula	C13H8F5NO
Molecular Weight	289.20 g/mol
Synonyms	4-Amino-3,5-difluoro-3'-(trifluoromethoxy)biphenyl; 3,5-Difluoro-3'-(trifluoromethoxy)biphenyl-4-amine; [1,1'-Biphenyl]-4-amine, 3,5-difluoro-3'-(trifluoromethoxy)-; 3,5-Difluoro-3'-(trifluoromethoxy)-4-biphenylamine; 4-Biphenylamine, 3,5-difluoro-3'-(trifluoromethoxy)-; 3,5-Difluoro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-4-ylamine
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-3'-(Trifluoromethoxy)-[1,1'-Biphenyl]-4-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for advanced chemical synthesis. Certificates of Analysis (COA) detailing specifications such as assay, impurity profile, and residual solvents are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store this material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.