Description

Dulanermin CAS NO 867153-61-5 is a recombinant human Apo2 ligand/TRAIL (Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand) protein, a key therapeutic agent designed to induce apoptosis in cancer cells. This compound is of significant interest for its targeted mechanism of action, offering a promising approach in oncology research and therapeutic development. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and academic institutions focused on developing novel cancer treatments and studying programmed cell death pathways.

Application

• Oncology Research: Fundamental studies on apoptosis induction and cancer cell death mechanisms.
• Therapeutic Development: A key active pharmaceutical ingredient (API) in the formulation of investigational anti-cancer biologics.
• Preclinical Studies: Used in in vitro and in vivo models to evaluate efficacy and safety profiles.
• Biomarker Research: Investigation of TRAIL receptor expression and signaling pathways in various malignancies.
• Combination Therapy Screening: Assessment of synergistic effects with chemotherapy, radiotherapy, or other targeted agents.
• Process Development: Serves as a reference standard in the development and validation of biomanufacturing and purification processes for recombinant proteins.

Basic Information

Product Name	Dulanermin
CAS No.	867153-61-5
Molecular Formula	C845H1323N223O255S10
Molecular Weight	Approx. 19.8 kDa
Synonyms	Recombinant Human Apo2L/TRAIL; Apo-2 Ligand; TNF-Related Apoptosis-Inducing Ligand; TRAIL/Apo2L; CD253; TNFSF10; APO2L; rhApo2L/TRAIL
EINECS	Contact for details

Quality Control

Our Dulanermin is produced under stringent quality management systems. Each batch is subjected to a comprehensive battery of analytical tests including identity confirmation, purity assessment, and biological activity assays to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing specifications for purity, endotoxin levels, sterility, and biological potency are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Bioactivity)	Contact for details
Endotoxin	< 1.0 EU/µg
Sterility	Sterile
Solubility	Soluble in sterile PBS or cell culture medium

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.