Description

2,2,2-Trifluoro-1-(Piperidin-4-Yl)Ethanone is a high-value trifluoromethyl ketone derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring a piperidine ring and a reactive trifluoroacetyl group, makes it indispensable for introducing fluorinated motifs into target molecules, which can dramatically alter their physicochemical and biological properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances bioactivity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and fluorination reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with unique surface properties.
• Chemical Biology Probes: Utilized in the design of activity-based probes and inhibitors for studying enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring the incorporation of a piperidine-trifluoromethyl ketone scaffold.

Basic Information

Product Name	2,2,2-Trifluoro-1-(Piperidin-4-Yl)Ethanone
CAS No.	866929-67-1
Molecular Formula	C7H10F3NO
Molecular Weight	181.16 g/mol
Synonyms	4-(Trifluoroacetyl)piperidine; 1-(Piperidin-4-yl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-piperidin-4-ylethanone; 4-Acetylpiperidine, 2,2,2-trifluoro-; Trifluoroacetylpiperidine; 4-Trifluoroacetylpiperidine; 1-(4-Piperidyl)-2,2,2-trifluoroethanone; 4-(2,2,2-Trifluoroacetyl)piperidine
EINECS	Contact for details

Quality Control

Every batch of 2,2,2-Trifluoro-1-(Piperidin-4-Yl)Ethanone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, GC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.