Description

Benzenepropanoic Acid, β-Amino-4-Fluoro-, Methyl Ester, (Betas)- is a specialized fluorinated amino acid derivative with significant utility in advanced organic synthesis. This compound matters as a key chiral building block for pharmaceutical research and development, enabling the creation of complex molecules with high biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Research: Used in developing novel, fluorinated active ingredients for crop protection agents, leveraging the fluorine atom's ability to modulate bioavailability and metabolic stability.
• Peptidomimetics & Bioactive Molecule Construction: Serves as a non-natural amino acid analog for designing peptide-like molecules with enhanced pharmacological properties.
• Chemical Biology Probes: Employed in the creation of labeled compounds and molecular probes for studying enzyme mechanisms and biological pathways.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale production of fluorinated fine chemicals.
• Academic & Institutional Research: A valuable reagent for methodological studies in asymmetric synthesis and fluorine chemistry.

Basic Information

Product Name	Benzenepropanoic Acid, β-Amino-4-Fluoro-, Methyl Ester, (Betas)-
CAS No.	866921-65-5
Molecular Formula	C₁₀H₁₂FNO₂
Molecular Weight	197.21 g/mol
Synonyms	(βS)-β-Amino-4-fluorobenzenepropanoic acid methyl ester; Methyl (3S)-3-amino-3-(4-fluorophenyl)propanoate; (S)-Methyl 3-amino-3-(4-fluorophenyl)propanoate; (S)-3-Amino-3-(4-fluorophenyl)propionic acid methyl ester; (S)-Methyl 3-amino-3-(p-fluorophenyl)propionate; 866921-65-5; (S)-MAPA methyl ester; 4-Fluoro-β-amino-benzenepropanoic acid methyl ester (S-enantiomer)
EINECS	Contact for details

Quality Control

Our Benzenepropanoic Acid, β-Amino-4-Fluoro-, Methyl Ester, (Betas)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic characterization are provided to guarantee identity, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (S-enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.