Description

2-Bromo-4-Fluoro-1-(Trifluoromethoxy)Benzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique molecular structure, featuring bromine, fluorine, and trifluoromethoxy substituents, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and inflammatory diseases.
• Agrochemical Synthesis: Serves as a versatile precursor for novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethoxy group.
• Liquid Crystal & OLED Materials: Used in the synthesis of advanced electronic materials for displays and lighting, where its halogenated structure contributes to desired electronic properties and stability.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig aminations, enabling rapid diversification of molecular scaffolds.
• Fluorine Chemistry Research: An important compound for studying the effects of fluorine and trifluoromethoxy substitution on aromatic systems in material science and drug design.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring high-purity, complex aromatic intermediates.

Basic Information

Product Name	2-Bromo-4-Fluoro-1-(Trifluoromethoxy)Benzene
CAS No.	866633-25-2
Molecular Formula	C7H3BrF4O
Molecular Weight	259.00 g/mol
Synonyms	1-Bromo-3-fluoro-4-(trifluoromethoxy)benzene; 2-Bromo-4-fluoro-1-(trifluoromethoxy)benzene; 3-Fluoro-4-(trifluoromethoxy)bromobenzene; Benzene, 2-bromo-4-fluoro-1-(trifluoromethoxy)-; 4-Fluoro-2-bromo-1-(trifluoromethoxy)benzene; 2-Bromo-4-fluoro-alpha,alpha,α-trifluoroanisole
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-value chemical intermediates. Every batch is analyzed using advanced techniques including GC, HPLC, and NMR to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) are available upon request, providing full transparency and traceability for your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture ingress and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.