Description

1-Bromo-4,5-difluoro-2-(trifluoromethoxy)benzene is a high-value, multi-functional fluorinated aromatic building block. Its unique structure, featuring bromine, fluorine, and a trifluoromethoxy group, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve lipophilicity and target binding.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs), influencing dielectric anisotropy and viscosity.
• Organic Electronics: Employed in the synthesis of novel materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and developing new fluorination methodologies.

Basic Information

Product Name	1-Bromo-4,5-difluoro-2-(trifluoromethoxy)benzene
CAS No.	866632-64-6
Molecular Formula	C7H2BrF5O
Molecular Weight	276.99 g/mol
Synonyms	2-Bromo-1,4-difluoro-5-(trifluoromethoxy)benzene; 4-Bromo-2,3-difluoro-1-(trifluoromethoxy)benzene; 1-Bromo-4,5-difluoro-2-(trifluoromethoxy)benzol; Benzene, 1-bromo-4,5-difluoro-2-(trifluoromethoxy)-; 4,5-Difluoro-2-(trifluoromethoxy)bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4,5-difluoro-2-(trifluoromethoxy)benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.