Description

(Z)-3-(2,4-Difluoroanilino)-3-Hydroxy-2-(3-Methoxybenzoyl)-2-Propenenitrile is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is of critical importance for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of proprietary drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, or anti-infective applications.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes due to its reactive nitrile and hydroxy groups.
• Process Chemistry: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales under current Good Manufacturing Practices (cGMP).
• Academic Research: Utilized in university and institutional labs for investigating new organic reactions, catalysis, and the development of novel synthetic methodologies.
• Agrochemical Intermediate: Potential application in the synthesis of advanced crop protection agents, leveraging the difluoroaniline moiety.

Basic Information

Product Name	(Z)-3-(2,4-Difluoroanilino)-3-Hydroxy-2-(3-Methoxybenzoyl)-2-Propenenitrile
CAS No.	866154-57-6
Molecular Formula	C17H12F2N2O3
Molecular Weight	330.29 g/mol
Synonyms	(Z)-3-(2,4-Difluoroanilino)-3-hydroxy-2-(3-methoxybenzoyl)acrylonitrile; 2-Propenenitrile, 3-((2,4-difluorophenyl)amino)-3-hydroxy-2-(3-methoxybenzoyl)-, (2Z)-; 3-((2,4-Difluorophenyl)amino)-3-hydroxy-2-(3-methoxybenzoyl)acrylonitrile (Z-isomer); DFMHP Intermediate; CAS 866154-57-6
EINECS	Contact for details

Quality Control

Our production of (Z)-3-(2,4-Difluoroanilino)-3-Hydroxy-2-(3-Methoxybenzoyl)-2-Propenenitrile adheres to stringent quality systems suitable for pharmaceutical development. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and traceability. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.