Description

3-Biphenyl-3',4'-Difluoro-Acetic Acid is a high-value fluorinated biphenyl acetic acid derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its precise molecular architecture, featuring strategically placed fluorine atoms on the biphenyl core, makes it indispensable for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical R&D departments for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Ligand Synthesis for Catalysis: Used to prepare sophisticated ligands for transition metal catalysts, enabling more efficient and selective cross-coupling reactions.
• Advanced Material Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Agrochemical Research: Employed in the discovery and development of new-generation herbicides and fungicides with improved efficacy and environmental profiles.
• Fluorine Chemistry Studies: A valuable substrate for investigating structure-activity relationships (SAR) and the effects of fluorine substitution in aromatic systems.

Basic Information

Product Name	3-Biphenyl-3',4'-Difluoro-Acetic Acid
CAS No.	866108-76-1
Molecular Formula	C14H10F2O2
Molecular Weight	248.23 g/mol
Synonyms	[3-(3,4-Difluorophenyl)phenyl]acetic acid; 2-[3-(3,4-Difluorophenyl)phenyl]acetic acid; 3'-Fluoro-4'-fluoro-3-biphenylacetic Acid; 3-(3,4-Difluorophenyl)benzenacetic acid; (3'-Fluoro-4'-fluoro-biphenyl-3-yl)-acetic acid; Biphenyl-3',4'-difluoro-acetic acid; 3-Biphenyl-3',4'-difluoroethanoic acid
EINECS	Contact for details

Quality Control

Every batch of 3-Biphenyl-3',4'-Difluoro-Acetic Acid is manufactured under strict quality management protocols. We provide comprehensive analytical documentation to support your research and development. Our standard quality commitment includes HPLC purity verification and full spectroscopic characterization (NMR, IR, MS). Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.