Description

4-(Trifluoromethyl)Cyclohex-1-Enylboronic Acid is a high-value organoboron building block used in advanced synthetic chemistry. Its core value lies in enabling the efficient construction of complex molecules containing the trifluoromethyl group, a key motif for enhancing metabolic stability and lipophilicity in active compounds. This boronic acid is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for Suzuki-Miyaura cross-coupling reactions to create novel drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical reagent in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially those targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used to incorporate the trifluoromethyl-cyclohexene moiety into new-generation herbicides, fungicides, and insecticides to improve efficacy and environmental profile.
• Material Science Research: Serves as a precursor for developing advanced organic electronic materials and liquid crystals, where the CF3 group fine-tunes electronic properties.
• Medicinal Chemistry: Enables rapid parallel synthesis and library development for structure-activity relationship (SAR) studies in early-stage drug discovery.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	4-(Trifluoromethyl)Cyclohex-1-Enylboronic Acid
CAS No.	865869-30-3
Molecular Formula	C7H10BF3O2
Molecular Weight	193.96 g/mol
Synonyms	4-(Trifluoromethyl)-1-cyclohexene-1-boronic acid; (4-(Trifluoromethyl)cyclohex-1-en-1-yl)boronic acid; 4-Trifluoromethyl-1-cyclohexenylboronic Acid; 4-(Trifluoromethyl)cyclohex-1-enylboronic acid; B-[4-(Trifluoromethyl)-1-cyclohexen-1-yl]boronic acid
EINECS	Contact for details

Quality Control

Every batch of 4-(Trifluoromethyl)Cyclohex-1-Enylboronic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider under an inert atmosphere to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.