Description

Acetic Acid, 2-Oxo-2-[(2,2,2-Trifluoroethyl)Amino]-, Ethyl Ester is a specialized fluorinated organic building block, identified by CAS NO 865814-65-9, that serves as a critical intermediate in advanced synthetic chemistry. Its molecular structure, featuring a trifluoroethylamino and an ethyl ester group, makes it a valuable precursor for constructing complex molecules with enhanced properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce fluorinated motifs to improve metabolic stability, bioavailability, and binding affinity in target compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the trifluoroethyl group can enhance lipophilicity and biological activity.
• Advanced Material Research: Serves as a building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials that require fluorinated components for specific performance characteristics.
• Peptidomimetics & Bio-conjugation: Employed in medicinal chemistry to create peptide analogs and for bio-conjugation strategies, leveraging its reactive ester and amide functionalities.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A high-value intermediate for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	Acetic Acid, 2-Oxo-2-[(2,2,2-Trifluoroethyl)Amino]-, Ethyl Ester
CAS No.	865814-65-9
Molecular Formula	C8H10F3NO3
Molecular Weight	225.17 g/mol
Synonyms	Ethyl 2-[(2,2,2-trifluoroethyl)amino]-2-oxoacetate; 2-Oxo-2-[(2,2,2-trifluoroethyl)amino]acetic Acid Ethyl Ester; N-(2,2,2-Trifluoroethyl)oxamidic Acid Ethyl Ester; Ethyl N-(Trifluoroethyl)oxamate; Oxamic Acid, N-(2,2,2-Trifluoroethyl)-, Ethyl Ester; Acetic Acid, [(2,2,2-Trifluoroethyl)Amino]oxo-, Ethyl Ester
EINECS	Contact for details

Quality Control

Our production of Acetic Acid, 2-Oxo-2-[(2,2,2-Trifluoroethyl)Amino]-, Ethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity for critical R&D and scale-up applications. All materials are characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support compliance with relevant regulatory frameworks for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); ensure containers are sealed under an inert atmosphere such as nitrogen to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.