Description

L-Norvaline, n-[(2S)-6,8-Difluoro-1,2,3,4-Tetrahydro-2-Naphthalenyl]- is a high-purity, fluorinated amino acid derivative designed for advanced research and pharmaceutical development. This compound is valued for its role as a specialized chiral building block in the synthesis of complex bioactive molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce specific fluorinated motifs that can enhance metabolic stability and bioavailability.
• Peptidomimetic Design: Incorporated into peptide analogs and peptidomimetics to modulate biological activity and improve pharmacokinetic properties.
• Chemical Biology Probes: Acts as a building block for creating labeled compounds or probes used to study enzyme mechanisms and protein interactions.
• Process Chemistry: Employed in the scale-up and route development for the commercial manufacturing of fluorinated drug candidates.

Basic Information

Product Name	L-Norvaline, n-[(2S)-6,8-Difluoro-1,2,3,4-Tetrahydro-2-Naphthalenyl]-
CAS No.	865774-79-4
Molecular Formula	C15H19F2NO2
Molecular Weight	283.32 g/mol
Synonyms	(2S)-2-[(6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl)amino]pentanoic acid; (S)-2-Amino-2-[(6,8-difluoro-3,4-dihydro-2H-naphthalen-1-yl)amino]pentanoic acid; L-2-Amino-2-[(6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl)amino]valeric acid; 6,8-Difluoro-1,2,3,4-tetrahydro-L-norvaline; Fluorinated L-Norvaline derivative; Difluorotetralin norvaline analog
EINECS	Contact for details

Quality Control

Our L-Norvaline, n-[(2S)-6,8-Difluoro-1,2,3,4-Tetrahydro-2-Naphthalenyl]- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. All materials are supported by comprehensive analytical data. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.