Description

Fmoc-Ala-Oh (U-13C3, U-15N) is a uniformly carbon-13 and nitrogen-15 labeled derivative of the amino acid alanine, protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This isotopically enriched compound is essential for advanced research in nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry, providing critical structural and dynamic insights into peptides and proteins. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in metabolic studies, proteomics, and the development of novel peptide-based therapeutics.

Application

• Isotopic Tracer in Metabolic Studies: Used to investigate amino acid metabolism, protein synthesis rates, and metabolic pathways in biological systems.
• NMR Spectroscopy: Serves as a crucial building block for the synthesis of isotopically labeled peptides and proteins for structural determination and dynamics analysis.
• Mass Spectrometry Standards: Employed as an internal standard for the accurate quantification of alanine and related peptides in complex biological matrices.
• Peptide & Protein Research: A key reagent in solid-phase peptide synthesis (SPPS) for producing labeled peptides used in drug discovery and biochemical assays.
• Proteomics and Biomarker Discovery: Facilitates stable isotope labeling by amino acids in cell culture (SILAC) and other quantitative proteomic techniques.

Basic Information

Product Name	Fmoc-Ala-Oh (U-13C3, U-15N)
CAS No.	865720-15-6
Molecular Formula	C133H1715NO4
Molecular Weight	Contact for details
Synonyms	Fmoc-L-alanine-13C3,15N; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanine-13C3,15N; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]propanoic acid-13C3,15N; Fmoc-Ala-OH (13C3, 15N); Fmoc-L-Ala-13C3,15N-OH; Uniformly Labeled Fmoc-Alanine; Isotopically Labeled Fmoc-Protected Alanine
EINECS	Contact for details

Quality Control

Our Fmoc-Ala-Oh (U-13C3, U-15N) is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for sensitive research applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm isotopic enrichment, chemical identity, and purity. Certificates of Analysis (COA) detailing isotopic purity (atom % 13C and 15N), chemical purity, and specific analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere (e.g., nitrogen or argon) when not in use. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom % 13C
Isotopic Purity (15N)	≥ 98 atom % 15N
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.