Description

4-Chloro-3-Fluorophenylacetic Acid is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound serves as a critical intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable, high-quality intermediates for their synthetic pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the chloro-fluoro substitution pattern enhances biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, such as Suzuki-Miyaura couplings, to introduce functionalized phenylacetic acid moieties.
• Peptidomimetic & Protease Inhibitor Research: The phenylacetic acid structure is valuable for creating non-peptide scaffolds in medicinal chemistry.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	4-Chloro-3-Fluorophenylacetic Acid
CAS No.	865451-00-9
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	(4-Chloro-3-fluorophenyl)acetic Acid; 2-(4-Chloro-3-fluorophenyl)acetic Acid; 4-Chloro-3-fluoro-benzeneacetic Acid; 865451-00-9; 4-Chloro-3-fluorophenylacetic acid; α-(4-Chloro-3-fluorophenyl)acetic Acid; 2-(4-Chloro-3-fluorophenyl)ethanoic Acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluorophenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.