Description

Tazarotene Sulfoxide is a key pharmaceutical intermediate and metabolite of the retinoid drug tazarotene. This compound matters for its critical role in the synthesis and analytical profiling of active pharmaceutical ingredients (APIs) used in dermatological treatments. It is primarily needed by manufacturers and research institutions in the pharmaceutical and fine chemical industries for drug development, quality control, and metabolic studies.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of the topical retinoid Tazarotene, used to treat psoriasis and acne.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Metabolite Studies: Used in pharmacokinetic and pharmacodynamic research to study the metabolism and biological activity of tazarotene.
• Impurity Profiling: Employed to identify and quantify related substances in active pharmaceutical ingredient (API) batches to ensure purity and safety.
• Research & Development: A vital reagent in medicinal chemistry for creating novel retinoid analogs and exploring new therapeutic applications.

Basic Information

Product Name	Tazarotene Sulfoxide
CAS No.	864841-56-5
Molecular Formula	C₂₁H₂₁NO₃S
Molecular Weight	367.46 g/mol
Synonyms	Ethyl 6-[(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate S-oxide; Tazarotenic Acid Sulfoxide; AGN 190299 Sulfoxide; AGN-190299 Sulfoxide; Tazarotene S-Oxide; TAZ Sulfoxide; (E)-Ethyl 6-((4,4-dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl)nicotinate S-oxide
EINECS	Contact for details

Quality Control

Our Tazarotene Sulfoxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and compliance with your research or production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.