Description

6-Fluoro-3-Methyl-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole is a high-value, multi-functional heterocyclic building block containing both an indazole core and a pinacol boronate ester group. This compound matters as a critical intermediate in modern pharmaceutical and agrochemical research, enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of novel drug candidates, particularly in kinase inhibitor and oncology therapeutic programs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex bioactive molecules, especially kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester functional group enables efficient palladium-catalyzed coupling with aryl/heteroaryl halides to construct biaryl structures.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and library synthesis to explore structure-activity relationships (SAR) around the indazole scaffold.
• Agrochemical Research: Intermediate in the development of new active ingredients for crop protection.
• Material Science: Potential precursor for organic electronic materials and ligands for catalysis.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process scale-up.

Basic Information

Product Name	6-Fluoro-3-Methyl-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole
CAS No.	864773-67-1
Molecular Formula	C₁₄H₁₈BFN₂O₂
Molecular Weight	276.11 g/mol
Synonyms	6-Fluoro-3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-fluoro-3-methyl-1H-indazole; 6-Fluoro-3-methyl-1H-indazole-5-boronic acid pinacol ester; 864773-67-1; 6-Fluoro-3-methyl-5-(pinacolboron)-1H-indazole; 5-Borono-6-fluoro-3-methyl-1H-indazole, pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 6-Fluoro-3-Methyl-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole is produced under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Comprehensive analytical data, including HPLC purity, NMR, and MS confirmation, is documented. Certificates of Analysis (COA) are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed and allowed to reach room temperature before opening to prevent condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.