Description

3-Fluoro-4-Trifluoromethyl-Phenylboronic Acid is a high-value, multi-fluorinated boronic acid derivative essential for modern synthetic chemistry. Its unique structure, featuring both fluorine and trifluoromethyl substituents, makes it a critical building block for introducing lipophilic and electron-withdrawing motifs into target molecules. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures via cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and thermal stability.
• Polymer & Resin Modification: Incorporated into specialty polymers to impart specific chemical resistance, lower dielectric constants, or alter surface properties.
• Chemical Research & Development: Employed in academic and industrial labs for methodological development in organometallic chemistry and the creation of compound libraries for drug discovery screening.
• Ligand & Catalyst Design: Useful for synthesizing novel bidentate or monodentate ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	3-Fluoro-4-Trifluoromethyl-Phenylboronic Acid
CAS No.	864759-68-2
Molecular Formula	C7H5BF4O2
Molecular Weight	207.92 g/mol
Synonyms	(3-Fluoro-4-(trifluoromethyl)phenyl)boronic acid; 3-Fluoro-4-(trifluoromethyl)benzeneboronic acid; B-[3-Fluoro-4-(trifluoromethyl)phenyl]boronic acid; 3-Fluoro-α,α,α-trifluoro-p-tolylboronic acid; 4-Borono-2-fluoro-α,α,α-trifluorotoluene; 2-Fluoro-α,α,α-trifluoro-4-boronobenzyl alcohol (tautomer)
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Trifluoromethyl-Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the stringent requirements for research and process chemistry. Certificates of Analysis (COA) documenting all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF Titration)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.