Description

3,5-Difluoro-4-Chlorophenylboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound matters for its pivotal role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. It is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials sectors for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro-chloro substitution pattern imparts unique biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and other transition metal-catalyzed processes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as monomers for conjugated polymers and small molecules for OLEDs and OFETs.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs serving the global life sciences industry.

Basic Information

Product Name	3,5-Difluoro-4-Chlorophenylboronic Acid
CAS No.	864759-63-7
Molecular Formula	C6H4BClF2O2
Molecular Weight	191.36 g/mol
Synonyms	(3,5-Difluoro-4-chlorophenyl)boronic acid; 4-Chloro-3,5-difluorophenylboronic acid; B-(3,5-Difluoro-4-chlorophenyl)boronic acid; 3,5-Difluoro-4-chloro-benzeneboronic acid; Boronic acid, B-(3,5-difluoro-4-chlorophenyl)-; 864759-63-7; (4-Chloro-3,5-difluorophenyl)boronic acid
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Chlorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are available for every shipment. We support compliance with relevant regulatory frameworks for our customers' target markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.