Description

n-Boc-D-Proline (2,2-Dimethoxy-Ethyl)-Methylamide is a high-purity, protected amino acid derivative designed for advanced synthetic chemistry. This compound is a critical chiral building block, offering precise stereochemical control for the construction of complex peptide and peptidomimetic structures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel therapeutic agents, including protease inhibitors and other bioactive molecules. The CAS number for this compound is 864754-42-7.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for protease-targeting drugs.
• Peptidomimetic Research: Used to introduce constrained proline analogs into peptide backbones to enhance metabolic stability and receptor selectivity.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected D-proline derivative for the automated synthesis of complex, non-natural peptide sequences.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore novel chemical space in drug discovery programs.
• Bioconjugation: Can be used to create functionalized linkers for antibody-drug conjugates (ADCs) or other bioconjugation strategies.
• Academic & Contract Research: Essential for academic laboratories and CROs (Contract Research Organizations) specializing in organic synthesis and peptide science.

Basic Information

Product Name	n-Boc-D-Proline (2,2-Dimethoxy-Ethyl)-Methylamide
CAS No.	864754-42-7
Molecular Formula	C15H28N2O5
Molecular Weight	316.40 g/mol
Synonyms	1-[(2,2-Dimethoxyethyl)(methyl)carbamoyl]-N-(tert-butoxycarbonyl)-D-proline; (2S)-1-[(2,2-Dimethoxyethyl)(methyl)carbamoyl]-N-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid; tert-Butyl (2S)-1-[(2,2-dimethoxyethyl)(methyl)carbamoyl]pyrrolidine-2-carboxylate; Boc-D-Pro-N(Me)(CH2CH(OCH3)2); D-Proline, 1-[(2,2-dimethoxyethyl)methylcarbamoyl]-, 1-(1,1-dimethylethyl) ester; 864754-42-7; Boc-D-Pro-DMAE-NMe
EINECS	Contact for details

Quality Control

Our n-Boc-D-Proline (2,2-Dimethoxy-Ethyl)-Methylamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of pharmaceutical development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.