Description

H2N-Peg4-Ch2Cootbu CAS NO 864680-64-8 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group and a tert-butyl ester-protected carboxylic acid. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the controlled linkage of biomolecules with precise spacing and solubility. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, proteomics, and advanced material science for creating PEGylated therapeutics, diagnostic agents, and functionalized surfaces.

Application

• Bioconjugation Linker: Used to covalently attach peptides, proteins, or antibodies to other molecules, surfaces, or nanoparticles via its amine-reactive and carboxyl-reactive ends.
• PEGylation Reagent: Serves as a spacer arm in the PEGylation of drugs to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Proteomics Research: Employed in the synthesis of cross-linking agents or affinity tags for studying protein-protein interactions and structural analysis.
• Drug Delivery Systems: Incorporated into the design of micelles, liposomes, and polymer-drug conjugates for targeted and controlled release applications.
• Surface Functionalization: Used to modify materials and biosensor surfaces with amine or carboxyl groups to improve biocompatibility and enable further coupling.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a soluble polymer support or as a component for introducing PEG spacers into synthetic peptide chains.

Basic Information

Product Name	H2N-Peg4-Ch2Cootbu
CAS No.	864680-64-8
Molecular Formula	C19H39NO8
Molecular Weight	409.52 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecan-14-oic acid, 14-amino-4-oxo-, 1,1-dimethylethyl ester; 1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid tert-butyl ester; Amine-PEG4-t-butyl ester; Boc-NH-PEG4-acid; NH2-PEG4-COOtBu; 15-Amino-4,7,10,13-tetraoxapentadecanoic acid tert-butyl ester; tert-Butyl 15-amino-4,7,10,13-tetraoxapentadecanoate
EINECS	Contact for details

Quality Control

Our H2N-Peg4-Ch2Cootbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.