Description

2-Ethoxy-5-Fluorophenylboronic Acid is a high-purity organoboron compound, a crucial building block in modern synthetic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient synthesis of complex biaryl structures. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those containing fluorinated biaryl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the 2-ethoxy-5-fluoro substitution pattern imparts specific biological activity.
• Material Science Research: Serves as a monomer or building block for constructing organic electronic materials, such as those used in OLEDs and semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Ethoxy-5-Fluorophenylboronic Acid
CAS No.	864301-27-9
Molecular Formula	C8H10BFO3
Molecular Weight	183.98 g/mol
Synonyms	(2-Ethoxy-5-fluorophenyl)boronic acid; 5-Fluoro-2-ethoxybenzeneboronic acid; 2-Ethoxy-5-fluorobenzeneboronic acid; Boronic acid, B-(2-ethoxy-5-fluorophenyl)-; 864301-27-9; 2-Ethoxy-5-fluorophenylboronic acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Every batch of our 2-Ethoxy-5-Fluorophenylboronic Acid is produced under strict quality management protocols. We employ advanced analytical techniques including HPLC, NMR (¹H, ¹³C, ¹¹B, ¹⁹F), and mass spectrometry to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (HPLC), with options for higher grades (≥98%, ≥99%) available. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) for prolonged storage or when opening the primary container to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.