Description

3-(2,2-Difluoroethoxy)Benzyl Bromide 95% is a high-purity, versatile benzyl bromide derivative featuring a difluoroethoxy substituent, making it a critical building block for advanced organic synthesis. Its primary value lies in its role as a key electrophilic intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for coupling reactions and molecular scaffolding.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to the fluorine-containing moiety which can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoroethoxy group can impart unique biological activity and environmental persistence profiles.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the synthesis of monomers and functional polymers, where the benzyl bromide group allows for polymerization or grafting onto surfaces.
• Chemical Biology Probes: Utilized to create tagged molecules or affinity probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-(2,2-Difluoroethoxy)Benzyl Bromide 95%
CAS No.	864054-55-7
Molecular Formula	C9H9BrF2O
Molecular Weight	251.07 g/mol
Synonyms	1-(Bromomethyl)-3-(2,2-difluoroethoxy)benzene; m-(2,2-Difluoroethoxy)benzyl Bromide; 3-(2,2-Difluoroethoxy)benzyl Bromide; (3-(2,2-Difluoroethoxy)phenyl)methyl Bromide; Benzene, 1-(bromomethyl)-3-(2,2-difluoroethoxy)-; α-Bromo-3-(2,2-difluoroethoxy)toluene; Difluoroethoxybenzyl Bromide
EINECS	Contact for details

Quality Control

Our 3-(2,2-Difluoroethoxy)Benzyl Bromide 95% is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure it meets the specified purity and identity criteria. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.