Description

2,6-Difluorobenzeneboronic acid, Pinacol ester is a high-purity, synthetically valuable organoboron reagent. This compound is a protected boronic acid derivative, offering enhanced stability and handling characteristics compared to its free acid form, which is critical for complex synthetic workflows. It serves as a key Suzuki-Miyaura cross-coupling building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce a 2,6-difluorophenyl moiety into target molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing difluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the 2,6-difluorophenyl group imparts specific biological activity.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable arylboron reagent for palladium-catalyzed carbon-carbon bond formation with various aryl/heteroaryl halides or triflates.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Material Science Research: Used in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs or OFETs, where fluorination tunes electronic properties.
• Chemical Biology & Probe Development: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes for diagnostic and research applications.

Basic Information

Product Name	2,6-Difluorobenzeneboronic acid, Pinacol ester
CAS No.	863868-37-5
Molecular Formula	C12H15BF2O2
Molecular Weight	240.06 g/mol
Synonyms	2,6-Difluorophenylboronic acid pinacol ester; (2,6-Difluorophenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(2,6-difluorophenyl)-1,3,2-dioxaborolane; 2-(2,6-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2,6-Difluorobenzeneboronic acid pinacol ester; B-(2,6-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2,6-Difluorobenzeneboronic acid, Pinacol ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring stringent material consistency, from R&D to scale-up production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) in a sealed container with desiccant to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.